Ciprofloxacin-induced paroxysmal atrial fibrillation.OA Case Stories

For quotation functions:
Bolognesi M, Bolognesi D. Ciprofloxacin-induced paroxysmal atrial fibrillation. OA Case Stories 2014 Mar 08;3(3):24.

Cardiovascular Drugs

M Bolognesi1*, D Bolognesi2


Authors affiliations

(1) Inside Common Drugs,Main Care – Asl 112 District of Cesena By way of Ungaretti 494 47521, Cesena, Italy

(2) Territorial Drugs, Main Care – Asl 112 District of Cesena By way of Lambruschini 307 47521, Cesena, Italy

* Corresponding writer Electronic mail:



Ciprofloxacin is a second era fluoroquinolone with a broad spectrum of antibacterial exercise. It has good
bioavailability after oral administration, good to glorious tissue penetration and is comparatively protected. Typically nicely tolerated, Ciprofloxacin stays one of many most secure amongst antibiotics with
remarkably few reactions. Ciprofloxacin nonetheless, can induce cardiotoxicity that’s related to elevated QT and QTC interval, motion potential prolongation, tachyarrhythmias and torsade de pointes. This report goals to spotlight attainable cardiac
toxicity brought on by one of the broadly used medication that are fluoroquinolones, particularly in sufferers over 60 and thus enhance our data of those phenomena.

Case report

This case report describes a affected person with an episode of paroxysmal atrial fibrillation induced by
Ciprofloxacin therapy for urinary tract an infection.


This paper has proven that Ciprofloxacin has cardiotoxic potential. Sufferers’ cardiac perform standing ought to
be thought-about earlier than initiating Ciprofloxacin medical use.


Mostly used medication, as fluoroquinolones are for non-cardiac situations can have surprising and severe cardiac
unwanted effects. Fluoroquinolones have demonstrated from the
starting of utilization, excessive security profiles. Particularly, Ciprofloxacin and Levofloxacin each stay the most secure and higher tolerated fluoroquinolones. The commonest uncommon opposed results associated to those medication contain the gastrointestinal tract and the central nervous system,
plus tendinopathy particularly in sufferers
beneath 30 years outdated [1]. An underlying cardiac abnormality generally is a predisposing issue.
The cardiovascular system may be concerned as a consequence of attainable incidence of arrhythmias in sufferers with underlying coronary heart illness, and
because of this the query of cardiac security in newer fluoroquinolones[2] has been raised. In sufferers taking Ciprofloxacin, atrial fibrillation was reported
most frequently inside 42 days of administration, with no change in occasion price over that point. Syncope and tachycardia have been additionally reported with Ciprofloxacin and Ofloxacin[3]. Cardiovascular opposed reactions similar to palpitations,
tachycardia, and phlebitis have very not often been reported within the knowledge sheet of the drug. We report right here a curious case report of paroxysmal atrial fibrillation following
administration of Ciprofloxacin for a decrease urinary an infection in a 61year-old male.

Case report

The authors report a case of paroxysmal atrial fibrillation presumably brought on by
Ciprofloxacin administrated for decrease urinary tract an infection in a 61 year-old wholesome male, being handled for gentle hypertension and nicely compensated sort 2 diabetes mellitus for a number of
years with ACE inhibitors (Enalapril 20 mg die) and oral
hypoglycaemic brokers (Metformin 500 mg, twice day by day).
After 3-4 days of Ciprofloxacin taken orally (500 mg, twice day by day) assumption for a febrile non-gonococcal urethritis appeared malaise, with dizziness and profuse sweating.
The affected person was additionally in
a confusional state with detection of arterial hypotension in absence
of palpitations or tachycardia. When the affected person got here to our rooms bodily examination revealed an irregular heartbeat with asynchronous pulse and resting ECG (Determine 1A) confirmed atrial fibrillation at excessive common ventricular response
with out haemodynamic
penalties. The affected person was despatched to the emergency division the place intravenous bolus beta-blocker was infused to
cut back the ventricular price (Determine 1B) and subsequently administered orally to manage the guts price, along with anticoagulant remedy to stop cardioembolic dangers. Ciprofloxacin was instantly interrupted. An
electrocardiogram, recorded two days later, confirmed early restoration of the sinus rhythm (Determine 2) and transthoracic mono and bidimensional echocardiography confirmed no structural abnormalities or valvular
illness and, indicated, regular dimension of the guts chambers, in
specific left atrium quantity, with good left ventricular systolic and diastolic perform. The affected person remained in sinus rhythm with out indicators of recurrence of asymptomatic atrial fibrillation as documented by 72-hour Holter monitoring, and in ECG management that adopted for a lot of days.

Panel A Resting Ecg reveals atrial fibrillation with excessive ventricular response; Panel B: Resting ECG reveals atrial fibrillation with regular ventricular price

Resting ECG reveals regular sinus rhythm


The onset of arrhythmias associated to the idea of Ciprofloxacin can’t be excluded beforehand. Actually,
in comparison with different quinolones there are quite a few studies regarding cardiovascular occasions similar to arrhythmia induced by Ciprofloxacin occurring inside 42 days of
administration. Just lately,
Siepman and
Kirch have reported
the primary case of
tachycardia presumably related to consumption of Moxifloxacin 4. Ciprofloxacin is usually protected and well-tolerated. The commonest opposed reactions embody gastro-intestinal tract, central
nervous system and haematological system. Just lately, growing instances of Ciprofloxacin-associated toxicity have been reported.
The mechanism of Ciprofloxacin cardio-toxicity has not been absolutely understood but, however medical expertise reveals that Ciprofloxacin can induce cardiotoxicity marked by elevated QT and QTC interval,
consequently prolongation of motion potential period. This modification will increase the chance of the onset of malignant arrhythmias similar to torsade de pointes[5]. As reported by Adikwu and Brambaifa Ciprofloxacin induced cardiotoxic impact could possibly be related
with blocking cardiac voltage—gated potassium channels notably the speedy element (IKr) of the delayed rectifier potassium
present [6];
eHealthMe examine from FDA studies (see Determine 3) says that 4.793
individuals have reported unwanted effects when taking Ciprofloxacin. Amongst them, 170 individuals had atrial fibrillation, with 80% of them aged over 60. The authors consider that on this case it is rather probably because of the induction of AF by Ciprofloxacin, though it’s identified that this occasion can occur in any
older sufferers affected by hypertension or diabetes. Most studies of atrial fibrillation (AF) induced by non-cardiovascular medication are case studies[8], and since AF is so widespread, it’s troublesome to find out if the
affiliation is causal or incidental. Nonetheless, regardless of the in-ability to breed AF with drug re-challenges that may assist causality, the presence of neurological opposed occasions throughout
initiation of remedy with Ciprofloxacin in addition to the following onset of atrial fibrillation plus the speedy disappearance of the arrhythmia a number of days after discontinuation of
antibiotic remedy, strengthens the suspicion of the trigger and impact relationship between drug consumption and the incidence of the arrhythmia. Additional affirmation of this remark
is the absence of structural cardiac abnormalities and the presence of regular sized coronary heart chambers not topic to valvular illness after echocardiography examination causes the authors to carry that
this case falls throughout the subject of cardiotoxicity due
to fluoroquinolones. This report goals at highlighting
attainable cardiac toxicity particularly in sufferers aged over 60 introduced on by fluoroquinolones, one of the broadly used medication administered to sufferers, and thus
to enhance our data of those phenomena. Moreover, this report intends to elucidate the problem in pro-arrhythmia
danger administration of those medication within the context of polypharmacy and possible interplay amongst numerous medication in sufferers with a number of comorbidities
and danger components regarding arrhythmias. One ought to take into accounts that fluoroquinolones are medication that work together with the hepatic cytochrome P450 system, thus any CYP450 modification may result in increased drug serum concentrations with
attainable proarrhythmic results. At present, consciousness of
the proarrhythmic potential of non-cardiac medication mixed
with logical, medical reasoning would assist mitigate the risk-factor and assist keep away from incorrect choices[7].

The eHealthMe examine from FDA report


In conclusion this paper has proven that Ciprofloxacin has cardiotoxic potential. Sufferers’ cardiac perform standing must be thought-about earlier than
initiating Ciprofloxacin medical use. Idiopathic paroxysmal atrial fibrillation may be attributed to the opposed results of cardiotoxic medication, amongst which we should additionally contemplate quinolones similar to


The authors declare that written knowledgeable consent was obtained from the affected person (or different accredited events)
for publication of this case report and accompanying photographs. A replica of the written consent is offered for overview by the Editorial Workplace/Chief Editor/Editorial Board members of this journal.


1. Sprandel KA, Rodvold KA. Security and tolerability of fluoroquinolones. Clin Cornerstone.
2003 Suppl 3:S29-36.

2. Rubinstein E, Camm J. Cardiotoxicity of fluoroquinolones. Journal of Antimicrobial Chemotherapy. 2002;49:593-596.

3. Meyler’s Facet Results of Cardiovascular Medicine (Google eBook). Entrance Cowl. Jeffrey Okay. Aronson. Elsevier, Mar 2, 2009.

4. Siepman M, Kirch W. Tachycardia related to
BMJ. 2001;322:23.

5. Altman D, Eggmann U, Amman P. Drug Induces QT Prolongation. Wiener Klinische Wochenschrift, 2008 Vol. 120 No. 5-6, pp. 128-135.

6. Adikwu E, Brambaifa N. Ciprofloxacin Cardiotoxicity and Hepatotoxicity in People and
Animals. Pharmacology &
Pharmacy. 2012, 3, 207-213.

7. Iannini PB, Tittoson GS. Evaluating the Danger of Cardiotoxicity. Pharmacotherapy. 2001 Vol. 21, No. 3, pp.

8. Van der Hooft CS, Heeringa J, Van Herpen G, Kors JA,
Kingma JH, Striker BH. Drug-induced atrial fibrillation. J Am Coll Cardiol. 2004; 44:2117-24.

Licensee to OAPL (UK) 2014. Inventive Commons Attribution License (CC-BY)

Click to comment

You must be logged in to post a comment Login

Leave a Reply

Most Popular

To Top